Chiu TH et al.N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski). In Vivo May 2003.
Dr. Chiu and his team studied the inhibitory effects of gypenosides on human cervix cancer. They found there is indeed an inhibitory effect. The mechanism appears to be that gypenosides inhibited NAT mRNA expression in human cervix cancer cells.
Chen WC et al. Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice. American Journal of Chinese Medicine 1996.
In this study researchers were interested in the effects on the immune system of radiation. They subjected mice to gamma radiation. They found reduced white blood cell counts as a result of the radiation treatment. However, Mice given Jiaogulan recovered their white blood cell counts more quickly.
Zhou Z. et al. Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study.The Journal of Chinese Medicine 1998.
Dr. Zhou at Shanghai Medical University gave hamsters a known carcinogen. A control group did not receive Jiaogulan and developed cancer as predicted. Two other groups were given Jiaogulan orally. Both groups showed remarked slowing of the cancerous growth. The inhibitory effects were directly correlated with the dosage amounts of Jiaogulan.
Chen JC et al. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios. 1999.
Dr. Chen and his team, found that human liver cancer cells treated for two days with gypenosides (the active ingredients in Jiaogulan) died via apoptosis. Normal cells in the cancerous tissue sample proliferated.
Qwa-fu Wang, et al. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Letters 2002
Reseachers at the Chinese Medical College in Taiwan studied the mechanism by which Jiaogulan kills liver cancer cells. They confirmed the results of the above study and identified a potential mechanism for this effect.
Wang, C. et al. A preliminary observation of preventive and blocking effect of Gynostemma pentaphyllum (Thunb) Makino on esophageal cancer in rats. Hua Xi Yi Ke Da Xue Xue Bao. 1995
In this study researchers found that rats injected with a known carcinogen developed fewer and less frequent tumors when allowed to ingest water infused with Jiaogulan. The development of cancer was also delayed by about 6 weeks suggesting to the researchers that Jiaogulan was having a direct inhibitory effect.