Jiaogulan found to improve endurance.

Li ChangJun; Wu XiaoLan; Lou XiaoJuan; Wu YaJun; Li Ang; Wang HaiYan. Protective effects of crude polysaccharide from Gynostemma pentaphyllum on swimming exercise-induced oxidative stress in rat. Journal Journal of Animal and Veterinary Advances 2012 Vol. 11 No. 10

In this study, the test subjects (rats) were fed Jiaogulan for 30 days and subjected to a swimming endurance test. Those subjects given Jiaogulan showed significantly longer swim times and, based on liver glycogen measurements after the swim, were likely to recover faster. This research suggests that Jiaogulan may be beneficial to athletes hoping to improve endurance and excercise recoevery.

Jiaogulan is found to resist immune suppression and restore healthy immune systems

Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum Components
Sun-A Im, Hyun Sook Choi, Soon Ok Choi, Ki-Hyang Kim, Seungjeong Lee, Bang Yeon Hwang, Myung Koo Lee and Chong Kil Lee*
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea
25 June 2012, Molecule

In this study Korean researchers suppressed the immune system of mice using electro-shock. Those animals that had been fed Jiaogulan for one week before the electro-shock did not develop suppressed immune systems while the subjects not receiving Gynostemma did. In a follow up, 1/2 the mice with suppressed immune systems were subsequently fed Jiaogulan and showed faster recovery of their immune systems than the group not receiving Jiaogulan.

Gynostemma Found to Lower Cholesterol and Reduce Liver Damage

R. Qin et al.Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Archives of Pharmacal Research, Volume 35, number 7 2012

Chinese researchers fed a high fat, high cholesterol diet to rats and caused them to ingest alchohol daily. They kept left one group untreated, gave two groups popular anti-cholesterol medications and gave 3 remaining groups varying dosages of Gynostemma. After 10 weeks, the groups given Gynostemma showed significantly lower LDL-cholesterol and triglycerides. Furthermore test for liver health showed the Gynostemma group also maintained better liver health. The researchers concluded, “These results suggested that gypenosides could prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress. “

Jiaogulan has Potential Preventive Effects on Myocardial Infarction

Xiong, WS et al. Protective effects of gypenosides on experimental myocardial infarction. Zhongguo Yao Li Xue Bao. 1990 Sept,11.

Dr. Xiong studied the effects of Jioagulan on myocardial infarction. He found in an animal study that the gypenosides in Jiaogulan reduced the size of myocardial infarctions and the free fatty acids in the blood serum. He suggests that the effect is related to the strong anti-oxidative properties of Jiaogulan.

Jiaogulan Linked to Nitric Oxide Production in Blood Vessels

Tanner, MA et al. The Direct Release of Nitric Oxide by Gypenosides Derived from the Herb Gynostemma pentaphyllum. Nitric Oxide Oct. 1999.

Dr. Tanner and his team from Vanderbilt University Medical Center investigated the vasorelaxation effects of Jiaogulan. They found that gypenosides from Jiaogulan caused the lining of blood vessels to release nitric oxide.. The nitric oxide release relaxed the blood vessels resulting in more efficient blood flow.

Jiaogulan found to be an “anti-thrombotic agent.”

Tan H et al. Antithrombotic effect of Gynostemma pentaphyllum Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 May;13.

Thrombosis is another term for blood clotting. Clots can lead to heart attack and stroke. Researchers in China found that a water extract from Jiaogulan “could inhibit significantly the platelet aggregation induced by ADP and compound agonists (P < 0.05), accelerate obviously the disaggregation (P < 0.05) and inhibit effectively the experimental thrombosis (P < 0.05). The delayed effects of GP on KPTT, PT, TT, AT, RVV-RT, RVV-CT suggested that this drug could decrease the activity of multiple coagulation factors. And it showed that GP could accelerate the erythrocyte electrophoresis rate. This study revealed that GP is an antithrombotic agent affecting the links of thrombotic chain.”

Jiaogulan May Produce Higher Coronary Flow and Lower Heart Rate

Chen, L.F., et al. Comparisons of the effects of Gypenosides and ginsenosides on cardiac function and hemodynamics in dogs. Zhongguo Yaolixue Yu Dulixue Zazhi. China 1990

Dr. Chen and his team studied the effects of jiaogulan and ginseng on the cardiovascular efficiency of dogs. They found that the dogs that received Jiaogulan significantly lowered their systolic and diastolic blood pressure and decreased their total peripheral, brain and coronary blood vessel resistance. Ginseng was found to have a similar but less significant effect.

Jiaogulan Linked to More Efficient Cardio Function

Zhou, Ying-Na et al. Effects of gypensosides-containing tonics on the pulmonary functions in exercise workloads. Journal of Guiyang Medical College. 1993

Researchers at the Guiyang Medical College in China conducted studies of 220 athletes and 30 average subjects using color DOPLER imaging. The study showed that just 30 minutes after receiving a dose of gypenosides, 100% of the test subjects showed positive effects. The effects measured included, increased stroke volume and cardiac output, decreased left ventricular end-systolic diameter and increased left ventricular end-diastolic diameter. The heart rate and blood pressure did not increase. This implies that Jiaogulan improved the efficiency of the pumping action of the heart such that the heart did not have to work as had to produce the same volume of blood flow.

Jiaogulan Linked to Nitric Oxide Production in Blood Vessels!

Tanner, MA et al. The Direct Release of Nitric Oxide by Gypenosides Derived from the Herb Gynostemma pentaphyllum. Nitric Oxide Oct. 1999.

Dr. Tanner and his team from Vanderbilt University Medical Center investigated the vasorelaxation effects of Jiaogulan. They found that gypenosides from Jiaogulan caused the lining of blood vessels to release nitric oxide.. The nitric oxide release relaxed the blood vessels resulting in more efficient blood flow.

Nitric Oxide is Key to Lowering Blood Pressure

Achike, F.I., et al. Nitric oxide, human diseases and the herbal products that affect the nitric oxide signaling pathway. Clinical and Experimental Pharmacology and Physiology, September 2003.

Researchers in Canada and Malaysia teamed up to research the stimulation of Nitric Oxide production by various herbal products. Nitric Oxide is believed a key factor in in controlling blood pressure because when released by the surface cells of blood vessels it causes the vessels to relax thus reducing blood pressure. the researchers found Jiaogulan to be one of the most effective herbs available in stimulating this reaction.